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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	LEVISOPRENALINE
Molecular formula	C11H17NO3
IUPAC name	4-[(1R)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
Molecular weight	211.261
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-0.6
Synonyms	4-[(1R)-1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol AC1Q1Q9S BSPBio_001174 Isopropyl norepinephrine Levisoprenalina Lopac-I-6504 NCGC00025274-01 UNII-L628TT009W component JWZZKOKVBUJMES-NSHDSACASA-N (R)-(-)-Isoproterenol (R)-Isoproterenol 51-31-0 BDBM50407517 CCG-204758 l-Isoprenaline Levisoprenaline [INN:DCF] NCGC00015558-02 Prestwick3_001097 (-)-alpha-(Isopropylaminomethyl)protocatechuyl alcohol 110537-43-4 AB00514693 BPBio1_001292 CHEMBL1160723 l-Isoproterenol Levoisoproterenol NCGC00016665-03 Tocris-1747 (-)-Isoproterenol hydrochloride (R)-(-)-Isoproterenol, crystalline 4-[(1R)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol AC1Q1Q9T C11703 Isoproterenol, L- Levisoprenalina [INN-Spanish] Lopac0_000672 PDSP1_001116 ZINC56652 1,2-Benzenediol, 4-((1R)-1-hydroxy-2-((1-methylethyl)amino)ethyl)- 588N0603CT Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamin)methyl)-, (-)- CHEBI:6257 l-Isopropylnoradrenaline Levisoprenalinum NCGC00015558-03 Proternol L (-)-Isoprenaline 137-95-1 AC1L9EJH BRN 3203136 DTXSID2043878 Levisoprenalin Lopac-I-5627 NCGC00016665-04 UNII-588N0603CT (-)-N-Isopropylnoradrenaline (R)-Isoprenaline ACM51310 CAS-5984-95-2 L-(-)-Isoproterenol NCGC00015558-01 PDSP2_001100 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (R)- 5FW Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-, (-)- L-Isopropylnorepinephrine Levisoprenalinum [INN-Latin] NCGC00016665-01 SCHEMBL250806 (-)-Isoproterenol [ Show all ]
Inchi Key	JWZZKOKVBUJMES-NSHDSACASA-N
Inchi ID	InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3/t11-/m0/s1
PubChem CID	443372
ChEMBL	CHEMBL1160723
IUPHAR	N/A
BindingDB	50407517
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<70000.0 nM	PMID17827	BindingDB
Ki	5600.0 nM	PMID17827	BindingDB

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