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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	tyramine
Molecular formula	C8H11NO
IUPAC name	4-(2-aminoethyl)phenol
Molecular weight	137.182
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.1
Synonyms	NCGC00016011-04 AS-11671 NCGC00016011-12 Biomol-NT_000075 NINDS_000918 BSPBio_002445 p-.beta.-Aminoethylphenol CS-W007606 DSSTox_RID_80079 2-(4-Hydroxyphenyl)ethylamine HMS2235J05 4- (2-aminoethyl)-Phenol KB-62189 4-Hydroxy-.beta.-phenylethylamine KS-00000NMU a-(4-Hydroxyphenyl)-b-aminoethane MCULE-3986856320 AJ-08146 Tenosin-wirkstoff Tyramine base Tyrosamine p-Hydroxy-beta-phenethylamine Phenol, 4-(2-aminoethyl)- SPECTRUM210400 ST24033343 alpha-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-07 BDBM29135 NCGC00063825-04 bmse000891 NSC249188 CCG-39684 p-Hydroxy-.beta.-phenylethylamine D0C5RZ .beta.-(4-Hydroxyphenyl)ethylamine EINECS 200-115-8 HY-W007606 4-(2-Aminoethyl)-phenol(thyramin) KBio2_004261 4-Hydroxy-beta-phenylethylamine Lopac-T-2879 AB0010532 MLS000079096 SY002127 Tox21_110282_1 Tyramine, 99% WLN: Z2R DQ p-Hydroxyphenethylamine SC-15191 Spectrum4_001801 NCGC00016011-02 AN-41614 NCGC00016011-10 beta-Hydroxyphenylethylamine NCGC00063825-07 BRD-K53893978-001-03-1 p-(2-aminoethyl)-Phenol CHEMBL11608 DSSTox_CID_23874 2-(4-Hydroxyphenyl)-ethylamine GTPL2150 21758-EP2314571A2 InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H 4-aminoethylphenol KBioGR_002405 51-67-2 LS-103913 ACMC-1AQH1 T-8911 Tyramin Tyramine, Vetec(TM) reagent grade, 99% [3H]-Tyramine P-hydroxy-b-phenethylamine para-Tyramine SMR000059295 SR-01000075365 AK-47332 NCGC00016011-05 b-(4-Hydroxyphenyl)ethylamine NCGC00016011-14 bmse000243 NSC 249188 C00483 p-beta-Aminoethylphenol CTK1G9434 (4-hydroxyphenyl)ethylamine DTXSID2043874 2-(p-Hydroxyphenyl)ethylamine HMS502N20 4-(2-amino-ethyl)-phenol KBio1_000918 4-Hydroxy-b-phenylethylamine KSC269I3J A0302 MFCD00008193 Tocosine Tyramine, 97% UNII-X8ZC7V0OX3 p-Hydroxy-beta-phenylethylamine Phenol, p-(2-aminoethyl)- Spectrum2_000738 ST51037693 alpha.-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-08 Benzeneethanamine, 4-hydroxy- NCGC00063825-05 BPBio1_001394 Opera_ID_887 CHEBI:15760 DB08841 2-(4'-Hydroxyphenyl)ethylamine FT-0651978 21758-EP2281563A1 I01-2032 4-(2-Aminoethyl)phenol KBio2_006829 4-Hydroxyphenethylamine Lopac0_001136 AC1L1KQE MolPort-000-698-914 Systogene to_000085 Tyramine, analytical standard X8ZC7V0OX3 p-Hydroxyphenylethylamine SCHEMBL4111 Spectrum5_000501 NCGC00016011-03 ANW-31318 NCGC00016011-11 BIDD:ER0507 NCGC00063825-08 BRN 1099914 p-(2-Aminoethyl)phenol cid_5610 DSSTox_GSID_43874 2-(4-hydroxyphenyl)ethanamine HMS1923C19 KB-204477 4-Hydroxy phenylethylamine KBioSS_001693 51T672 M-3365 AEF TC-060462 Tyramine;4-(2-Amino-ethyl)-phenol [3H]tyramine P-hydroxy-b-phenylethylamine Phenethylamine, p-hydroxy- SPBio_000696 SR-01000075365-5 AKOS000156022 NCGC00016011-06 BBL027695 NCGC00016011-16 bmse000870 NSC-249188 CAS-51-67-2 p-Hydroxy-.beta.-phenethylamine D01VFT .alpha.-(4-Hydroxyphenyl)-.beta.-aminoethane DZGWFCGJZKJUFP-UHFFFAOYSA-N HSDB 2132 4-(2-aminoethyl)-Phenol KBio2_001693 4-hydroxy-Benzeneethanamine L-Tyramine AB00051887-15 MFCD00149002 STK531130 Tox21_110282 Tyramine, 98%, FG Uteramine p-hydroxy-phenylethylamine RTC-060462 Spectrum3_000693 NCGC00016011-01 AM20060645 NCGC00016011-09 beta-(4-Hydroxyphenyl)ethylamine NCGC00063825-06 BR-47332 Oprea1_294339 DivK1c_000918 2-(4-hydroxy-phenyl)ethylamine GTPL2148 21758-EP2298312A1 IDI1_000918 4-13-00-01788 (Beilstein Handbook Reference) KBio3_001665 4-Hydroxyphenylethylamine LS-103895 AC1Q54AZ T-8910 TRA0098101 Tyramine, free base ZINC2233 p-Tyramine SGCUT00017 Spectrum_001213 [ Show all ]
Inchi Key	DZGWFCGJZKJUFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
PubChem CID	5610
ChEMBL	CHEMBL11608
IUPHAR	2150, 2148
BindingDB	29135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5900.0 nM	PMID17827	BindingDB
Ki	23000.0 nM	PMID17827	BindingDB

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