You can:
Name | Platelet-activating factor receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | PTAFR |
Synonym | PAFr PAF-R PAF receptor AGEPC receptor |
Disease | Nerve injury Ocular allergy Pain Unspecified Psoriasis [ Show all ] |
Length | 342 |
Amino acid sequence | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN |
UniProt | P25105 |
Protein Data Bank | 5zkq, 5zkp |
GPCR-HGmod model | P25105 |
3D structure model | This structure is from PDB ID 5zkq. |
BioLiP | BL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414 |
Therapeutic Target Database | T87023 |
ChEMBL | CHEMBL250 |
IUPHAR | 334 |
DrugBank | BE0005561 |
Name | CHEMBL282666 |
---|---|
Molecular formula | C28H19FN4O3 |
IUPAC name | 2-[3-[6-(2-fluorophenyl)-1-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][4,1]benzoxazepin-8-yl]prop-2-ynyl]isoindole-1,3-dione |
Molecular weight | 478.483 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 3.4 |
Synonyms | 2-{3-[6-(2-Fluoro-phenyl)-1-methyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[e]azulen-8-yl]-prop-2-ynyl}-isoindole-1,3-dione BDBM50011647 |
Inchi Key | DBDRVZPLYRUKRB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H19FN4O3/c1-17-30-31-25-16-36-26(21-10-4-5-11-23(21)29)22-15-18(12-13-24(22)33(17)25)7-6-14-32-27(34)19-8-2-3-9-20(19)28(32)35/h2-5,8-13,15,26H,14,16H2,1H3 |
PubChem CID | 14894759 |
ChEMBL | CHEMBL282666 |
IUPHAR | N/A |
BindingDB | 50011647 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 500.0 nM | PMID2002463 | BindingDB,ChEMBL |
ID50 | 0.04 mg.kg-1 | PMID2002463 | ChEMBL |
Inhibition | 0.0 % | PMID2002463 | ChEMBL |
Inhibition | 99.0 % | PMID2002463 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417