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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd3
Synonym	D3 receptor D3R Dopamine D3 receptor dopaminergic receptor D3
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UniProt	P19020
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3138
IUPHAR	216
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	Biomol-NT_000037 STK368596 Levosulpiridum [INN-Latin] BRN 0494008 Sulpiride [USAN:INN:BAN:JAN] MCULE-7506797476 Championyl Sulpiridum [INN-Latin] MolPort-002-070-475 Darleton Tox21_302205 NCGC00015966-05 Dogmatyl (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide NCGC00255813-01 Eglonil (RS)-(+/-)-sulpiride o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- Fardalan 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide Prestwick3_000056 HMS3263A22 AC-12181 RD 1403 HY-B1019 BCP13871 SMR000038923 Kylistro Levopraid BPBio1_000463 Sulpirida LP01050 Calmoflorine Sulpiride, SLP Miradol CHEMBL26 Sulpride N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat Z84655412 NCGC00015966-08 Dresent (+/-)-Sulpiride NINDS_000278 Enimon Oprea1_602476 GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) PubChem17241 HMS3372O01 AKOS004912732 S 8010 Isnamide Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- SR-01000075402 SR-01000075402-6 Levosulpiride [INN] BRD-A55272860-001-04-7 Sulpiride (JP17/USAN/INN) Magnetic resonance imaging sulpiride CCRIS 4248 Sulpiride-R MLS000069434 CTK8F2082 Sursumid N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide NCGC00015966-03 Dobren (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide NCGC00024852-04 DSSTox_RID_80050 (plusmn)-sulpiride Nufarol EU-0101050 15676-16-1 Prestwick1_000056 HMS2095K13 AB0105833 R. D. 1403 HMS3712K13 AN-1019 SCHEMBL8421 KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Biomol-NT_000162 Sulperide Lisopiride BSPBio_000211 Sulpiride, British Pharmacopoeia (BP) Reference Standard Meresa CHEBI:32168 Sulpitil N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Tox21_501050 NCGC00015966-06 Dogmatyl (TN) (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide NCGC00261735-01 Eglonyl (RS)-(A+/-)-Sulpiride Omiryl Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide Prestwick_431 HMS3266P12 AC1L1K62 Restful I06-0054 BDBM11638 SPBio_002132 L-Sulpiride SR-01000075402-2 Levosulpirida BPBio1_001255 Sulpirida [INN-Spanish] LS-20058 CAS-15676-16-1 SULPIRIDE,(+) Mirbanil Coolspan Sulpyrid N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 Zemorcon ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide NCGC00024852-02 DSSTox_CID_22574 (.+/-.)-Sulpiride Norestran Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Ozoderpin Guastil Pyrikappl HMS3393A08 Alimoral S0501 J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- BGRJTUBHPOOWDU-UHFFFAOYSA-N Stamonevrol Levosulpiridum BRD-A55272860-001-08-8 Sulpiride 1.0 mg/ml in Methanol Mariastel CCRIS-4248 Sulpiridum MLS001306443 D01226 Synedil NCGC00015966-04 Dogmatil (+-)-sulpiride NCGC00024852-05 DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- Eusulpid 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Prestwick2_000056 HMS2231K07 Abilit R.D. 1403 HMS500N20 BCP04500 Sernevin KS-00000YBQ BPBio1_000233 Sulpirid Lopac0_001050 C15H23N3O4S Sulpiride, European Pharmacopoeia (EP) Reference Standard MFCD00055061 Sulpor N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Valirem NCGC00015966-07 Dolmatil (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide Neogama EINECS 239-753-7 (y)-Sulpiride Omperan FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide Psicocen HMS3371P16 Aiglonyl RV-12309 IDI1_000278 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- Splotin L000579 SR-01000075402-3 Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 LS-20059 CCG-205127 SULPIRIDE,(-) Misulvan CS-4534 Suprium N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide dl-sulpiride ( inverted question mark)-Sulpiride NCGC00024852-03 DSSTox_GSID_42574 (?)-Sulpiride Normum EU-0001755 Prestwick0_000056 HMS1568K13 676S161 Pyrkappl HMS3651G12 AN-1017 s4655 KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.71 nM	PMID10327430	BindingDB
Ki	8.0 nM	PMID11171942	BindingDB
Ki	21.0 nM	PMID10327430	BindingDB
Ki	25.0 nM	PMID1975644	BindingDB
Ki	70.0 nM	PMID8301592	BindingDB
Ki	206.7 nM	PMID8301592	BindingDB
Ki	422.0 nM	PMID1975644	BindingDB

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