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Name | Prostaglandin D2 receptor |
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Species | Homo sapiens (Human) |
Gene | PTGDR |
Synonym | PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like [ Show all ] |
Disease | Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis [ Show all ] |
Length | 359 |
Amino acid sequence | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL |
UniProt | Q13258 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q13258 |
3D structure model | This predicted structure model is from GPCR-EXP Q13258. |
BioLiP | N/A |
Therapeutic Target Database | T68782 |
ChEMBL | CHEMBL4427 |
IUPHAR | 338 |
DrugBank | BE0000296 |
Name | BW A868C |
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Molecular formula | C25H37N3O5 |
IUPAC name | 7-[1-benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxoimidazolidin-4-yl]heptanoic acid |
Molecular weight | 459.587 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 1.7 |
Synonyms | CC-00140 HMS3648M13 PDSP1_000938 7-(1-benzyl-3-(2-cyclohexyl-2-hydroxyethylamino)-2,5-dioxoimidazolidin-4-yl)heptanoic acid BW A868C, >=98% (HPLC) [ Show all ] |
Inchi Key | YZJVWSKJHGEIBL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31) |
PubChem CID | 122021 |
ChEMBL | N/A |
IUPHAR | 1899, 1897 |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 1.58489 nM | PMID11082108 | IUPHAR |
Ki | 0.501187 - 2.51188 nM | PMID7642548, PMID2924081, PMID9579725 | IUPHAR |
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