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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger2
Synonym	EP2 receptor PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProt	Q62928
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4909
IUPHAR	341
DrugBank	N/A

Ligand

Name	19(R)-hydroxy-PGE2
Molecular formula	C20H32O6
IUPAC name	(Z)-7-[(1R,2R,3R)-2-[(E,3S,7R)-3,7-dihydroxyoct-1-enyl]-3-hydroxy-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight	368.47
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	1.3
Synonyms	19(R)-hydroxy Prostaglandin E2 19R-19-Hydroxy PGE-2 GTPL1947 19(R)-OH-PGE2 9-Oxo-11R,15S,19R-trihydroxy-5Z,13E-prostadienoate NCGC00161298-01 (Z)-7-[(1R,2R,3R)-2-[(E,3S,7R)-3,7-dihydroxyoct-1-enyl]-3-hydroxy-5-oxocyclopentyl]hept-5-enoic acid BML1-G11 SR-01000946845-1 19R-hydroxy-PGE2 LMFA03010024 19-Hydroxy-PGE2 9-oxo-11R,15S,19R-trihydroxy-5Z,13E-prostadienoic acid SCHEMBL2630490 1279AH 19R-(OH)-PGE2 D05MXO ZINC12495318 19(R)-hydroxy-Prostaglandin E2 64625-54-3 MolPort-027-640-887 19-OH-PGE2 AC1NR1DV SR-01000946845 [ Show all ]
Inchi Key	WTJYDBMHYPQFNJ-ZUVVJKHESA-N
Inchi ID	InChI=1S/C20H32O6/c1-14(21)7-6-8-15(22)11-12-17-16(18(23)13-19(17)24)9-4-2-3-5-10-20(25)26/h2,4,11-12,14-17,19,21-22,24H,3,5-10,13H2,1H3,(H,25,26)/b4-2-,12-11+/t14-,15+,16-,17-,19-/m1/s1
PubChem CID	5283038
ChEMBL	N/A
IUPHAR	1947
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	158.489 nM	PMID9537820	IUPHAR

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