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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	(R)-3-Hydroxybutanoic acid
Molecular formula	C4H8O3
IUPAC name	(3R)-3-hydroxybutanoic acid
Molecular weight	104.105
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-0.5
Synonyms	(R)-3-Hydroxybutyric acid, >=98.0% (T) 3-delta-hydroxybutyrate AC1L3NHP beta-D-Hydroxybutyric acid CH-195 D-beta-Hydroxybutyric acid EINECS 210-909-6 KS-00000LLQ TC-154483 (R)-(-)-b-Hydroxybutyrate (R)-(-)-beta-Hydroxybutyric acid 148ULJ1DF4 3HR AK-89074 Butanoic acid, 3-hydroxy-, (R)- CS-0044101 delta-3-hydroxybutyrate H-4010 MLS001333960 (-)-3-Hydroxy-n-butyric acid WHBMMWSBFZVSSR-GSVOUGTGSA-N 3-D-hydroxybutyrate 82578-46-9 ANW-65738 Butyric acid, 3-hydroxy-, D-(-)- D-3-hydroxybutyric acid DS-18570 I04-8422 SCHEMBL60959 (3R)-3-hydroxybutanoic acid (R)-(-)-b-Hydroxybutyric acid (R)-beta-Hydroxybutanoic acid 3-delta-hydroxybutyric acid AC1Q5T3J BHIB CHEBI:17066 D0R4GX FT-0605155 LMFA01050243 UNII-148ULJ1DF4 (R)-3- 3R-hydroxy-butanoic acid AKOS016843355 BUTANOIC ACID,3-HYDROXY-, BUTYL ESTER, (3R)- CTK5E9838 delta-3-hydroxybutyric acid HMS2230E08 MolPort-003-824-844 (-)-3-Hydroxybutyric acid ZINC895486 (R)-3-Hydroxybutyric acid 3-D-hydroxybutyric acid 9438AB BDBM50412190 C01089 D-beta-hydroxybutyrate DTXSID3041829 KB-210138 SMR000857294 (R)-(-)-3-Hydroxybutyric acid (R)-(-)-beta-hydroxybutyrate (R)-beta-Hydroxybutyric acid 3-Hydroxybutanoic acid, (R)- AJ-24195 Butanoic acid, 3-hydroxy-, (3R)- CHEMBL1162484 delta-(-)-3-hydroxybutyrate GTPL1593 MFCD00066257 UNII-TZP1275679 component WHBMMWSBFZVSSR-GSVOUGTGSA-N (R)-3-Hydroxybutanoate 3-(R)-Hydroxybutyric acid 625-72-9 AN-46832 Butanoic acid,3-hydroxy-,butyl ester,(3R)- D-(-)-3-hydroxybutyrate delta-beta-hydroxybutyrate HY-W051723 NCGC00246976-01 (-)-beta-Hydroxybutyrate, D- [ Show all ]
Inchi Key	WHBMMWSBFZVSSR-GSVOUGTGSA-N
Inchi ID	InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/t3-/m1/s1
PubChem CID	92135
ChEMBL	N/A
IUPHAR	1593
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	794328.0 nM	PMID15929991	IUPHAR

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