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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Proto-oncogene Mas
Species	Rattus norvegicus (Rat)
Gene	Mas1
Synonym	angiotensin 1-7 receptor MAS MAS1 MAS1 proto-oncogene MAS1 proto-oncogene, G protein-coupled receptor
Disease	N/A for non-human GPCRs
Length	324
Amino acid sequence	MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSQSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSTFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV
UniProt	P12526
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	150
DrugBank	N/A

Ligand

Name	AR 244555
Molecular formula	C23H23ClF2N2O
IUPAC name	(1'-but-3-enyl-5-chlorospiro[2H-indole-3,4'-piperidine]-1-yl)-(2,6-difluorophenyl)methanone
Molecular weight	416.897
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.2
Synonyms	MolPort-042-665-829 ZINC169620334 D0Z2FF (1'-but-3-enyl-5-chlorospiro[2H-indole-3,4'-piperidine]-1-yl)-(2,6-difluorophenyl)methanone NCGC00386715-01 AR-244555 GTPL7042 SCHEMBL5578980 AR244555 [ Show all ]
Inchi Key	QKPSTNGNDWHYCH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23ClF2N2O/c1-2-3-11-27-12-9-23(10-13-27)15-28(20-8-7-16(24)14-17(20)23)22(29)21-18(25)5-4-6-19(21)26/h2,4-8,14H,1,3,9-13,15H2
PubChem CID	59004159
ChEMBL	N/A
IUPHAR	7042
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	348.0 nM	PMID22003054	IUPHAR

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