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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Mus musculus (Mouse)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
UniProt	P35375
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2181
IUPHAR	340
DrugBank	N/A

Ligand

Name	Dpt-prostaglandin E1
Molecular formula	C22H30O5
IUPAC name	7-[(1R,2R)-2-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]heptanoic acid
Molecular weight	374.477
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.5
Synonyms	MampB-28767 70K4BF31QF M&B 28,767 PDSP2_001534 11-Deoxy-16-phenoxy-17,18,19,20-tetranor-PGE1 Cyclopentaneheptanoic acid, 2-(3-hydroxy-4-phenoxy-1-butenyl)-5-oxo-, (1R-(1alpha,2beta(1E,3R*)))- M&B28767 7-[(1R,2R)-2-[(E,3R)-3-hydroxy-4-(phenoxy)but-1-enyl]-5-oxocyclopentyl]heptanoic acid GTPL1913 MB 28767 80558-61-8 M&B 28767 UNII-70K4BF31QF 11-Deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 D0BN1U MampB 28767 7-[(1R,2R)-2-[(E,3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]heptanoic acid LS-58019 MB-28767 AC1NSK8W M&B-28767 [ Show all ]
Inchi Key	NZGFSDWJUZOAAX-KAVAACISSA-N
Inchi ID	InChI=1S/C22H30O5/c23-18(16-27-19-8-4-3-5-9-19)14-12-17-13-15-21(24)20(17)10-6-1-2-7-11-22(25)26/h3-5,8-9,12,14,17-18,20,23H,1-2,6-7,10-11,13,15-16H2,(H,25,26)/b14-12+/t17-,18+,20+/m0/s1
PubChem CID	5311223
ChEMBL	N/A
IUPHAR	1913
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	125.893 nM	PMID9313928	IUPHAR

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