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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 4
Species	Mus musculus (Mouse)
Gene	Ccr4
Synonym	chemokine (C-C motif) receptor 4 CD194 CCR4 CCR-4 CC-CKR-4 CC CKR4 C-C CKR-4 C-C chemokine receptor 4 ChemR13 [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYTEHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
UniProt	P51680
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5410
IUPHAR	61
DrugBank	N/A

Ligand

Name	AZD-1678
Molecular formula	C11H8Cl2FN3O3S
IUPAC name	2,3-dichloro-N-(5-fluoro-3-methoxypyrazin-2-yl)benzenesulfonamide
Molecular weight	352.161
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.6
Synonyms	AZD1678 NWSUDJQTTGDPIR-UHFFFAOYSA-N compound 49 [PMID: 28947948] 2,3-dichloro-N-(5-fluoro-3-methoxypyrazin-2-yl)-benzenesulfonamide SCHEMBL1966740 GTPL9679 2,3-dichloro-N-(5-fluoro-3-methoxypyrazin-2-yl)benzenesulfonamide [ Show all ]
Inchi Key	NWSUDJQTTGDPIR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H8Cl2FN3O3S/c1-20-11-10(15-5-8(14)16-11)17-21(18,19)7-4-2-3-6(12)9(7)13/h2-5H,1H3,(H,15,17)
PubChem CID	23585443
ChEMBL	N/A
IUPHAR	9679
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.0 nM	PMID28947948	IUPHAR

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