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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Mus musculus (Mouse)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R gnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKLQKWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPLAVQSNSKLEQSMISLAWILSIVFAGPQLYIFRMIYLADGSGPTVFSQCVTHCSFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	Q01776
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3232679
IUPHAR	256
DrugBank	N/A

Ligand

Name	Lutrepatch
Molecular formula	C60H73N15O13
IUPAC name	N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	1212.34
Hydrogen bond acceptor	14
Hydrogen bond donor	15
XlogP	0.5
Synonyms	GnRH I Luteinizing hormone releasing hormone salmon, >=97% (HPLC) Anti-infertility peptide (iontophoretic/Smart Patch), Ferring/Vyteris GnRH (Lutrepatch, female fertility) GTPL1162 GnRH (Smart Patch, female infertility), Ferring/Vyteris LH-RH (LHRH) Anti-infertility peptide (iontophoretic/Smart Patch), Vyteris/Ferring Gonadotropin-releasing hormone (Smart Patch, female infertility), Ferring/Vyteris GnRH (Lutrepatch, female fertility), Ferring Iontophoretic anti-infertility peptide (Smart Patch), Ferring/Vyteris GnRH (Smart Patch, female infertility), Vyteris/Ferring Luteinizing hormone releasing hormone salmon D0R9VC Gonadotropin-releasing hormone (Smart Patch, female infertility), Vyteris/Ferring PYR-HIS-TRP-SER-TYR-GLY-TRP-LEU-PRO-GLY-NH2 GnRH (Lutrepatch, female infertility), Ferring/Vyteris Iontophoretic anti-infertility peptide (Smart Patch), Vyteris/Ferring [ Show all ]
Inchi Key	NMJREATYWWNIKX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)
PubChem CID	16132914
ChEMBL	N/A
IUPHAR	1162
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	12.0 - 17.0 nM	PMID26774084	IUPHAR
IC50	5.01187 nM	PMID1328228	IUPHAR

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