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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-arachidonyl glycine receptor
Species	Homo sapiens (Human)
Gene	GPR18
Synonym	GPCRW G-protein coupled receptor 18 N-arachidonoyol glycine receptor NAGly receptor GPR18
Disease	N/A
Length	331
Amino acid sequence	MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProt	Q14330
Protein Data Bank	N/A
GPCR-HGmod model	Q14330
3D structure model	This predicted structure model is from GPCR-EXP Q14330.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2384898
IUPHAR	89
DrugBank	BE0002304

Ligand

Name	O-1602
Molecular formula	C17H22O2
IUPAC name	5-methyl-4-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene-1,3-diol
Molecular weight	258.361
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	4.5
Synonyms	5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL D06NAM O-1602 compound AKOS024457297 HVJ SR-01000946749 5-Methyl-4-((1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-1,3-benzenediol CHEMBL3402654 O 1602 5-methyl-4-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene-1,3-diol GTPL5525 RT-014805 (1'R,2'R)-5',6-dimethyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro[1,1'-biphenyl]-2,4-diol B7191 J-018524 SR-01000946749-1 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol CTK8E7356 HMS3649P12 SCHEMBL3763279 317321-41-8 BN0716 MolPort-003-983-886 ZINC35636061 [ Show all ]
Inchi Key	KDZOUSULXZNDJH-LSDHHAIUSA-N
Inchi ID	InChI=1S/C17H22O2/c1-10(2)14-6-5-11(3)7-15(14)17-12(4)8-13(18)9-16(17)19/h7-9,14-15,18-19H,1,5-6H2,2-4H3/t14-,15+/m0/s1
PubChem CID	45073499
ChEMBL	N/A
IUPHAR	5525
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	65.3 nM	PMID21595653	IUPHAR

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