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GLASS

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GPCR

Name	P2Y purinoceptor 4
Species	Rattus norvegicus (Rat)
Gene	P2ry4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 NRU uridine nucleotide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	361
Amino acid sequence	MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGLCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAIRWGRPRFASLLCLGVWLVVAGCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLLQADCHVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSKPKPRTAASSLALVTLHEESISRWADTHQDSTFSAYEGDRL
UniProt	O35811
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2124
IUPHAR	325
DrugBank	N/A

Ligand

Name	Affi gel blue
Molecular formula	C29H20ClN7O11S3
IUPAC name	1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid
Molecular weight	774.147
Hydrogen bond acceptor	18
Hydrogen bond donor	7
XlogP	4.4
Synonyms	Cibacronblau F3G-A L000507 UNII-5DV0L8V99J component JQYMGXZJTCOARG-UHFFFAOYSA-N 1-Amino-4-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid 12237-92-2 778536-90-6 C.I. 61211 EINECS 235-465-0 Procion Blue H-B 1-amino-4-(4-(4-chloro-6-(3-sulfophenylamino)-1,3,5-triazin-2-ylamino)-3-sulfophenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo- AC1LCVHE CHEBI:34946 Cibacron Blue F 3GA GTPL1739 SCHEMBL1638291 1-AMINO-4-[[4-[[4-CHLORO-6-[(3-SULFOPHENYL)AMINO]-1,3,5-TRIAZIN-2-YL]A MINO]-3-SULFO-PHENYL]AMINO]-9,10-DIOXO-ANTHRACENE-2-SULFONIC ACID 2-Anthraquinonesulfonic acid, 1-amino-4-(4-((4-chloro-6-m-sulfoanilino-S-triazin-2-yl)amino)-3-sulfoanilino)- Basilen Blue CTK4F8482 LS-172530 UNII-J0A052J6QF 1-amino-4-((4-((4-chloro-6-((sulfophenyl)amino)- 1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)- 9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid 79241-87-5 C.I. Reactive Blue 2 CHEMBL1160031 FT-0699643 Reactive blue 2 (C.I. 61211) 1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfo-anilino]-9,10-dioxo-anthracene-2-sulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-(4-((4-chloro-6-(sulfoanilino)-s-triazin-2-yl)amino)-3-sulfoanilino)-9,10-dihydro-9,10-dioxo- Cibacron Blue F(3)GA J0A052J6QF T654 1-Amino-4-((4-((4-chloro-6-((3(or4)-sulphophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulphophenyl)amino)-9,10-dihydro-9,10-dioxoanthracene-2-sulphonic acid 1-amino-4-[[4-[[4-chloro-6-[(3-sulfophenyl)amino]-1,3,5-triazin-2-yl]amino]-3-sulfophenyl]amino]-9,10-dioxoanthracene-2-sulfonic acid 26763-68-8 BDBM50179359 D06GJP NSC 328383 ZINC8295160 1-Amino-4-((4-((4-chloro-6-((sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-((4-((4-chloro-6-((3(or 4)-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo- 802902-10-9 C13746 Cibacron Blue 3G FT-0699654 Reactive Blue-2 1-amino-4-[4-[[4-chloro-6-(3-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid 2-Anthracenesulfonic acid, 1-amino-4-(4-((4-chloro-6-(sulfoanilino)-s-triazin-2-yl)amino)-3-sulfoanilino)-9,10-dihydro-9,10-dioxo- (8CI) Affi-gel blue [ Show all ]
Inchi Key	JQYMGXZJTCOARG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-13-4-3-5-15(10-13)49(40,41)42)37-29(36-27)34-18-9-8-14(11-20(18)50(43,44)45)32-19-12-21(51(46,47)48)24(31)23-22(19)25(38)16-6-1-2-7-17(16)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37)
PubChem CID	656725
ChEMBL	N/A
IUPHAR	1739
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	19952.6 nM	PMID9647463	IUPHAR

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