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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Oxoeicosanoid receptor 1
Species	Homo sapiens (Human)
Gene	OXER1
Synonym	R527 oxoeicosanoid (OXE) receptor 1 OXE receptor hGPCR48 GPR170 G-protein coupled receptor TG1019 G-protein coupled receptor R527 G-protein coupled receptor 170 5-oxo-ETE receptor 5-oxo-ETE G-protein coupled receptor TG1019 [ Show all ]
Disease	N/A
Length	423
Amino acid sequence	MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
UniProt	Q8TDS5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628461
IUPHAR	271
DrugBank	N/A

Ligand

Name	5S-HpETE
Molecular formula	C20H32O4
IUPAC name	(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
Molecular weight	336.472
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	5.3
Synonyms	5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid 5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid CHEMBL1743204 JNUUNUQHXIOFDA-JGKLHWIESA-N SR-01000946955-1 (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid 5-(S)-hydroperoxyeicosatetraenoic acid AC1NQXKH HMS1361I07 NCGC00161249-01 (5s)-5-hydroperoxy-(e,z,z,z)-6,8,11,14-eicosatetraenoic acid 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid 5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid C05356 HMS3402I07 SCHEMBL1394974 (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid (S)-5-HPETE 5(S)-Hydroperoxyeicosatetraenoic acid 6,8,11,14-Eicosatetraenoic acid, 5-hydroperoxy-, (S-(E,Z,Z,Z))- D0Q2LG LMFA03060012 ZINC8219830 5(S)-HPETE 5-Hydroperoxy-6,8,11,14-eicosatetraenoic acid BML1-C04 HMS1791I07 NCGC00161249-02 (5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate CHEBI:15632 IDI1_033915 SR-01000946955 (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate 1436AH 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid 71774-08-8 GTPL2483 LS-63791 5(S)-Hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate BSPBio_001445 HMS1989I07 NCGC00161249-03 (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate [ Show all ]
Inchi Key	JNUUNUQHXIOFDA-JGKLHWIESA-N
Inchi ID	InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
PubChem CID	5280778
ChEMBL	N/A
IUPHAR	2483
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	100.0 nM	PMID16039985	IUPHAR

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