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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Rattus norvegicus (Rat)
Gene	Grm4
Synonym	glutamate receptor GPRC1D mGlu4 receptor mGluR4
Disease	N/A for non-human GPCRs
Length	912
Amino acid sequence	MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
UniProt	P31423
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2787
IUPHAR	292
DrugBank	N/A

Ligand

Name	cppg
Molecular formula	C11H14NO5P
IUPAC name	2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid
Molecular weight	271.209
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-3.1
Synonyms	183364-82-1 BN0162 cyclopropyl-4-phosphonophenylglycine SCHEMBL7370655 AC1L1EOB CHEBI:125380 L023979 W-206310 (RS)-CPPG alpha-cyclopropyl-4-phosphonophenylglycine CPPG, >=98% (HPLC) RP00336 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid BRD-A24951056-001-01-4 D06PHE SR-01000597486 ACM183364821 CHEMBL164642 MolPort-003-983-544 Y8058 amino(cyclopropyl)(4-phosphonophenyl)acetic acid CTK7I4170 RT-015310 2-Cyclopropyl-2-(4-phosphonophenyl)glycine C11H14NO5P GTPL1413 SR-01000597486-1 (RS)-?-Cyclopropyl-4-phosphonophenylglycine AKOS024458717 NCGC00024912-02 [ Show all ]
Inchi Key	IGODGTDUQSMDQU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)
PubChem CID	2878
ChEMBL	N/A
IUPHAR	1413
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	25118.9 nM	PMID10187777	IUPHAR

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