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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 4
Species	Homo sapiens (Human)
Gene	P2RY4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 P2P NRU uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	365
Amino acid sequence	MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
UniProt	P51582
Protein Data Bank	N/A
GPCR-HGmod model	P51582
3D structure model	This predicted structure model is from GPCR-EXP P51582.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2123
IUPHAR	325
DrugBank	N/A

Ligand

Name	inosine triphosphate
Molecular formula	C10H15N4O14P3
IUPAC name	[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	508.165
Hydrogen bond acceptor	16
Hydrogen bond donor	7
XlogP	-5.1
Synonyms	5'-ITP CHEMBL1233686 Inosine 5'-triphosphate LS-84004 UNII-212A76R77X ({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid AC1Q6S2R EINECS 205-046-7 [[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate 2'-inosine-5'-triphosphate C00081 Inosine 5'-(tetrahydrogen triphosphate) ITP 5-ITP D00WOK Inosine 5(tetrahydrogen triphosphate) O(5')-(tetrahydroxytriphosphoryl)inosine ZINC8215530 132-06-9 AJ-57364 GTPL1743 Inosine tripolyphosphate 212A76R77X CHEBI:16039 Inosine 5'-(tetrahydrogen triphosphate) (8CI,9CI) ITT AC1L1RAP DTXSID8074499 Inosine 5-triphopshate SCHEMBL163281 [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate bmse000255 Inosine 5 Inosine-5'-Triphosphate [ Show all ]
Inchi Key	HAEJPQIATWHALX-KQYNXXCUSA-N
Inchi ID	InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID	135398643
ChEMBL	N/A
IUPHAR	1743
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7943.28 nM	PMID10779375	IUPHAR

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