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GLASS

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GPCR

Name	Metabotropic glutamate receptor 5
Species	Rattus norvegicus (Rat)
Gene	Grm5
Synonym	glutamate receptor GPRC1E mGlu5 receptor mGluR5
Disease	N/A for non-human GPCRs
Length	1203
Amino acid sequence	MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
UniProt	P31424
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2564
IUPHAR	293
DrugBank	N/A

Ligand

Name	(S)-4-CARBOXY-3-HYDROXYPHENYLGLYCINE
Molecular formula	C9H9NO5
IUPAC name	4-[(S)-amino(carboxy)methyl]-2-hydroxybenzoic acid
Molecular weight	211.173
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-1.0
Synonyms	AC1NSKO9 NCGC00024532-02 UNII-M725GQ103A component GXZSAQLJWLCLOX-ZETCQYMHSA-N 4-Carboxy-3-hydroxyphenylglycine, (S)- B6255 D0S6DK SCHEMBL12648356 (S)-4C3H-PG Benzeneacetic acid, alpha-amino-4-carboxy-3-hydroxy-, (S)- MolPort-003-983-491 Tocris-0320 4-((S)-Amino-carboxy-methyl)-2-hydroxy-benzoic acid AKOS024457474 CHEMBL39372 PDSP1_001316 ZINC2559031 (S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]-2-hydroxybenzoic acid BDBM50053585 DFS3SIU1ME SR-01000597633 (s)-4C3HPG 85148-82-9 BN0022 NCGC00024532-01 UNII-DFS3SIU1ME 4-Carboxy-3-hydroxy-L-phenylglycine B6253 CTK8F2145 PDSP2_001300 4C3HPG Benzeneacetic acid, alpha-amino-4-carboxy-3-hydroxy-, (alphaS)- GTPL1374 SR-01000597633-1 [ Show all ]
Inchi Key	GXZSAQLJWLCLOX-ZETCQYMHSA-N
Inchi ID	InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15)/t7-/m0/s1
PubChem CID	5311455
ChEMBL	CHEMBL39372
IUPHAR	1374
BindingDB	50053585
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2511.89 nM	PMID11080213	IUPHAR

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