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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	ethopropazine
Molecular formula	C19H24N2S
IUPAC name	N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine
Molecular weight	312.475
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.8
Synonyms	Isothiazine L001334 N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine Pardidol 10-(2-(Diethylamino)propyl)-phenothiazin Parsidan (TN) 10H-Phenothiazine-10-ethanamine, N,N-diethyl-alpha-methyl- Phenothiazine, 10-[2-(diethylamino)propyl]- Athapropazine Profenamina CHEBI:313639 Prophenamine diethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine SCHEMBL34045 Fempropazine Spectrum_000815 W 483 KBio2_003863 Lysivane (Salt/Mix) N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine Parkin 10-[2-(Diethylamino)-1-Propyl]phenothiazine Parsitan Prestwick2_000840 BPBio1_000879 Profenamine D0Q0RC Rocipel EINECS 208-320-4 SPBio_002720 GTPL7181 Isotazin KBioGR_001215 N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine NINDS_000061 Parphezein (Salt/Mix) 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE Phenoprozine AC1L1FLK Prodictazin (Salt/Mix) BSPBio_002018 Profenaminum DB00392 SBI-0051378.P003 Spectrum4_000548 KBio1_000061 LS-105451 N,N-diethyl-1-phe-nothiazin-10-yl-propan-2-amine Pardisol (Salt/Mix) 10-(2-DIETHYLAMINOPROPYL)-PHENOTHIAZINE Parsidol 2-Diethylamino-1-propyl-N-dibenzoparathiazine Prestwick0_000840 Athopropazin Profenamina [INN-Spanish] CHEMBL1206 Prophenaminum DivK1c_000061 SKF 2538 Fenpropazina SR-05000001626 W-483 KBio2_006431 MCULE-1873220615 NCGC00178860-03 Parkin (TN) 10-[2-(Diethylamino)-2-methylethyl]phenothiazine Parsotil AB00053474 Prestwick3_000840 BRD-A16311756-003-01-0 Profenamine (INN) DB-040867 Rodipal Ethapropazine Spectrum2_000984 IDI1_000061 Isothazine KBioSS_001295 N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine # Parcidol (.+/-.)-Profenamine Parsidan 10H-Phenothiazine-10-ethanamine, N,N-diethyl-.alpha.-methyl- PHENOTHIAZINE, 10-(2-(DIETHYLAMINO)PROPYL)- Aethopropropazin Prodierazine CDOZDBSBBXSXLB-UHFFFAOYSA-N Profenaminum [INN-Latin] Dibutil (Salt/Mix) SC 2538 Etopropezina Spectrum5_001592 SR-05000001626-4 KBio2_001295 Lysivane N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine Parfezine 10-(2-Diethylaminopropyl)phenothiazine Parsidol(TN) 522-00-9 Prestwick1_000840 BDBM8958 Profenamina [Italian] D08426 Rochipel DTXSID2023018 SPBio_001047 FT-0697105 KBio3_001238 N,N-Diethyl-.alpha.-methyl-10H-phenothiazine-10-ethanamine NCIOpen2_008174 Parkisol 10-[2-(Diethylamino)propyl]phenothiazine Phenopropazine AB00053474_04 Prodictazin BSPBio_000799 Profenamine [INN:BAN] RP 3356 Ethopromazine Spectrum3_000429 Isopthazine [ Show all ]
Inchi Key	CDOZDBSBBXSXLB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
PubChem CID	3290
ChEMBL	N/A
IUPHAR	7181
BindingDB	N/A
DrugBank	DB00392
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.2 nM	PMID2904117	IUPHAR

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