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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-arachidonyl glycine receptor
Species	Homo sapiens (Human)
Gene	GPR18
Synonym	GPCRW G-protein coupled receptor 18 N-arachidonoyol glycine receptor NAGly receptor GPR18
Disease	N/A
Length	331
Amino acid sequence	MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProt	Q14330
Protein Data Bank	N/A
GPCR-HGmod model	Q14330
3D structure model	This predicted structure model is from GPCR-EXP Q14330.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2384898
IUPHAR	89
DrugBank	BE0002304

Ligand

Name	AM251
Molecular formula	C22H21Cl2IN4O
IUPAC name	1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
Molecular weight	555.241
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	6.5
Synonyms	AOB33718 Bio2_000245 C20220 CS-3920 HMS1361M07 HMS3651B15 KBio3_000490 MLS001424171 1h-pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-n-1-piperidinyl- NCGC00025011-02 AC1Q5Q3V SMR000466284 BCP9000280 BN0063 CCG-101124 DB-004430 HMS2052K15 J-011727 KS-0000180H 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carboxamide N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 2208AH RT-011260 AM 251 (pharmaceutical) SR-01000597360-6 UNII-3I4FA44MAI Bio1_000608 BSPBio_001525 CHEMBL285932 FT-0661538 HMS3402M07 KBio2_005381 MFCD01861181 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide NC00374 4CA-0138 SB19550 AM251, >98% (HPLC), solid BC600320 Bio2_000725 C22H21Cl2IN4O CTK8E9265 HMS1791M07 HY-15443 KBioGR_000245 MolPort-003-983-507 1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl- NCGC00025011-03 AKOS024456393 SR-01000597360 SW197754-2 BDBM21279 BRD-K92000912-001-02-7 CHEBI:90724 DTXSID7042695 HMS3267K22 KBio2_000245 L000964 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide s2819 AM-251 ZINC1997139 Bio1_001097 BUZAJRPLUGXRAB-UHFFFAOYSA-N CPD000466284 GTPL3317 HMS3649G04 KBio3_000489 MLS000758233 183232-66-8 NCGC00025011-01 AC1L1CZ3 SCHEMBL1040316 AM251/AM-251 BCP21728 BML3-F08 CBiol_001833 D08YQT HMS1989M07 IDI1_033995 KBioSS_000245 N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide NCGC00025011-04 AM 251 SR-01000597360-1 Tocris-1117 Bio1_000119 BRD-K92000912-001-06-8 EX-A696 HMS3394K15 KBio2_002813 LS-184236 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide N-Piperidino-1-(2,4-dichlorophenyl)-4-methyl-5-(4-iodophenyl)-1H-pyrazole-3-carboxamide 3I4FA44MAI SAM001247081 [ Show all ]
Inchi Key	BUZAJRPLUGXRAB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
PubChem CID	2125
ChEMBL	CHEMBL285932
IUPHAR	3317
BindingDB	21279
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	96400.0 nM	PMID21595653	IUPHAR

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