Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype prostaglandin E receptor 3 prostanoid EP3 receptor
Disease	N/A for non-human GPCRs
Length	365
Amino acid sequence	MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWSDQLER
UniProt	P34980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5674
IUPHAR	342
DrugBank	N/A

Ligand

Name	prostaglandin D2
Molecular formula	C20H32O5
IUPAC name	(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.6
Synonyms	LS-125822 (5z,13e)-(15s)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate ZINC85994848 (5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oate (5Z,9alpha,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid 198163-EP2272825A2 5179-EP2281815A1 AC1L9LZD CHEBI:15555 GTPL1891 NCGC00161284-02 RXY07S6CZ2 (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid [3H]PGD2 (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate 11-Dehydroprostaglandin F2-alpha 41598-07-6 5179-EP2305640A2 BHMBVRSPMRCCGG-OUTUXVNYSA-N D0H8QQ HMS1989K08 Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9-alpha,13E,15S)- (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoate SR-01000946237-1 (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate (5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oate 5179-EP2281563A1 9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoate BSPBio_001486 E8965369-341A-46F4-8677-2CEB4F9432BA IDI1_033956 MFCD00077857 Prostaglandin D2, >=95%, synthetic (5z,13e)-(15s)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid [3H]-PGD2 (5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid 198163-EP2272827A1 5179-EP2295409A1 AKOS032954030 CHEMBL1235252 HMS1361K08 NCGC00161284-03 (5E,13E)-9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID SCHEMBL2508829 (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate [3H]prostaglandin D2 (5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oate 11-Dehydroprostaglandin F2alpha 5179-EP2272832A1 5179-EP2316459A1 BML1-F05 HMS3402K08 LMFA03010004 prosta-glandin d2 (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoic acid UNII-RXY07S6CZ2 (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid (5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid 198163-EP2270004A1 5179-EP2281813A1 9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoic acid C00696 GTPL1881 NCGC00161284-01 Prostaglandin D2, cell culture tested (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate [3H]11-dehydroprostaglandin F2-alpha (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid 11-Dehydroprostaglandin F2 alpha 2004AH 5179-EP2301937A1 BDBM21544 D06KBO HMS1791K08 PGD2 (5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]hept-5-enoic acid SR-01000946237 (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid (5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oic acid 5179-EP2280006A1 5179-EP2316824A1 BRN 2170623 DB02056 HMS3648M03 [ Show all ]
Inchi Key	BHMBVRSPMRCCGG-OUTUXVNYSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
PubChem CID	448457
ChEMBL	N/A
IUPHAR	1891, 1881
BindingDB	N/A
DrugBank	DB02056
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	13.0 nM	PMID9537820	IUPHAR
Ki	1.3 nM	PMID9537820	IUPHAR
Ki	1258.93 nM	PMID9537820	IUPHAR

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417