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GLASS

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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	(+)-sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[[(2R)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	Eglonyl (TN) Hoechst Brand of Sulpiride Levosulpiride [INN] NCGC00015966-01 Pontiride S 8010 (R)-(+)-5-aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Sulpiride (JP15/USAN/INN) Sulpor BDBM81775 vertigo neogama D03QGM FT-0630504 KS-00000XKE Lopac-S-7771 Neuraxpharm (TN) R-(+)-sulpiride SCHEMBL15475031 (R)-sulpiride Sulpiride-high,(-) Allphar Brand of Sulpiride Tocris-0894 Bosnyl (TN) ZINC20229 Desitin Brand of Sulpiride Dogmatyl (TN) Hennig Brand of Sulpiride Levopraid Meresa (TN) PDSP2_001633 Rosemont Brand of Sulpiride Sulperide 4109R0VM5R Sulpiryd (TN) Arminol Uriach Brand of Sulpiride Ekilid Hormosan Brand of Sulpiride Levosulpiride-d3 NCGC00015966-02 Psicofarma Brand of Sulpiride Sanofi Synthelabo Brand of Sulpiride (R)-(+)-sulpiride Sulpiride, (+)- AC1LD7D1 Sulpride Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (R)- Vertigo-Meresa Deponerton Fumouzer Brand of Sulpiride Lebopride Lopac-S-8010 PDSP1_000619 R. D. 1403 Spyfarma Brand of Sulpiride (RS)-( inverted exclamation markA)-Sulpiride Sulpiride-low,(-) Almirall Brand of Sulpiride UNII-4109R0VM5R Centrum Brand of Sulpiride Digton Dolorgiet Brand of Sulpiride Hexal Brand of Sulpiride Levosulpirida N-[[(2R)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide Pharmacia Brand of Sulpiride RV-12309 (inverted question mark)-Sulpiride Sulpirid (TN) Sulpivert B6492 Vertigo Meresa CHEMBL196677 Erempharma Brand of Sulpiride Krewel Brand of Sulpiride Levosulpiridum NCGC00024852-01 R(+)-SULPIRIDE Sanofi-Synthelabo Brand of Sulpiride (R)-(-)-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-o-anisamide Sulpiride-d ACM124020275 Tepavil Benzamide, 5-(aminosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-methoxy- vertigo-neogama Desisulpid GTPL960 Levobren Magnetic resonance imaging sulpiride PDSP2_000617 Ratiopharm (TN) Sulp 23756-79-8 Sulpiride-R Areu Brand of Sulpiride UNII-7MNE9M8287 component BGRJTUBHPOOWDU-LLVKDONJSA-N CHEBI:64122 Dogmatil (TN) [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-LLVKDONJSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m1/s1
PubChem CID	643497
ChEMBL	CHEMBL196677
IUPHAR	960
BindingDB	81775
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2200.0 nM	PMID8967990	IUPHAR

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