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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	ADTN
Molecular formula	C10H13NO2
IUPAC name	6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol
Molecular weight	179.219
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.4
Synonyms	SR-01000075362 2,3-Naphthalenediol,6-amino-5,6,7,8-tetrahydro- 6,7-Dihydroxy-2-aminotetralin BSPBio_001023 D0X2NO KBio2_005079 MLS002172466 NCGC00162147-03 2-aminotetralin-6,7-diol 6-Amino-5,6,7,8-tetrahydro-naphthalene-2,3-diol CHEMBL26736 HMS1792C05 KBioGR_002511 NCGC00015291-04 PDSP1_000820 53463-78-8 6-azanyl-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide Biomol-NT_000003 cMAP_000069 KB-199024 Lopac0_000415 NCGC00162147-01 SCHEMBL3126243 SR-01000075362-6 2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene 6,7-Dihydroxy-3-chromanamine AC1L1FAH CCG-204507 FT-0645288 KBio2_007647 NCGC00015291-02 NCGC00162147-04 (+)-ADTN 2-aminotetralin-6,7-diol;hydrobromide 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol AKOS006328808 cid_11957526 HMS1990C05 KBioSS_002519 NCGC00015291-05 PDSP2_000476 SMR001254097 2,3-Naphthalenediol, 6-amino-5,6,7,8-tetrahydro- 6,7-Adtn BPBio1_001127 CTK4J8115 KBio2_002511 LS-175452 NCGC00162147-02 2-Amino-6,7-dihydroxytetralin 6-Amino-5,6,7,8-tetrahydro-2,3-naphthalenediol AC1Q79PY GTPL932 KBio3_002989 NCGC00015291-03 PDSP1_000478 (+)-ADTN (aminotetralin-6,7-diol) 463A788 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide BDBM81195 cid_3153 HMS3403C05 L000081 NCGC00015291-06 PDSP2_000807 [ Show all ]
Inchi Key	ASXGAOFCKGHGMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
PubChem CID	3153
ChEMBL	CHEMBL26736
IUPHAR	932
BindingDB	81195
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1000.0 nM	PMID1826762	IUPHAR

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