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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Nociceptin receptor
Species	Rattus norvegicus (Rat)
Gene	Oprl1
Synonym	NOP receptor NOP-r NOPr OP4 Orphanin FQ receptor ROR-C NOCIR nociceptin/orphanin FQ receptor nociceptin receptor ORL1 N/OFQ receptor MOR-C KOR-3 kappa3-related opioid receptor Kappa-type 3 opioid receptor XOR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	367
Amino acid sequence	MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProt	P35370
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4503
IUPHAR	320
DrugBank	N/A

Ligand

Name	CHEMBL196932
Molecular formula	C26H21BrN2O4
IUPAC name	1-[8-[[(2S,4S,6S)-17-bromo-3,13-dioxatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),7,9,11,15,17-hexaen-4-yl]methyl]-7-oxa-8-azabicyclo[4.2.0]octa-1(6),2,4-trien-3-yl]azetidin-2-one
Molecular weight	505.368
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.3
Synonyms	BDBM50167758 1-[8-((2S,3aS,12bS)-11-Bromo-2,3,3a,12b-tetrahydro-1,8-dioxa-dibenzo[e,h]azulen-2-ylmethyl)-7-oxa-8-aza-bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl]-azetidin-2-one
Inchi Key	DAPJKUQVQBYJJK-IAKTWSEQSA-N
Inchi ID	InChI=1S/C26H21BrN2O4/c27-15-5-7-23-20(11-15)26-19(18-3-1-2-4-22(18)32-23)13-17(31-26)14-29-21-12-16(6-8-24(21)33-29)28-10-9-25(28)30/h1-8,11-12,17,19,26H,9-10,13-14H2/t17-,19-,26-/m0/s1
PubChem CID	44402627
ChEMBL	CHEMBL196932
IUPHAR	N/A
BindingDB	50167758
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2458.0 nM	PMID15911276	BindingDB,ChEMBL

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