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GPCR

Name	Delta-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRD1
Synonym	D-OR-1 DOR opioid receptor OP1 DOP DOPr DOR-1 Delta receptor [ Show all ]
Disease	Cough Overactive bladder disorder Bladder disease Moderate-to-severe pain Diarrhea-predominant IBS Major depressive disorder Urinary incontinence Rheumatoid arthritis Premature ejaculation Pain Acute migraine Ischemic heart diseases Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease Alcohol use disorders Anxiety disorder [ Show all ]
Length	372
Amino acid sequence	MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
UniProt	P41143
Protein Data Bank	4rwd, 4rwa, 4n6h
GPCR-HGmod model	P41143
3D structure model	This structure is from PDB ID 4rwd.
BioLiP	BL0303696,BL0303697, BL0265712, BL0265705,BL0265706,BL0265707,, BL0303699,BL0303701, BL0303698,BL0303700
Therapeutic Target Database	T58992
ChEMBL	CHEMBL236
IUPHAR	317
DrugBank	BE0000420

Ligand

Name	cannabidiol
Molecular formula	C21H30O2
IUPAC name	2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
Molecular weight	314.469
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	6.5
Synonyms	(-)-trans-Cannabidiol 18436-46-9 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol 521-37-9 Cannabidiol (USAN/INN) CHEBI:69478 Delta(1(2))-trans-cannabidiol Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, (-)-(E)- 1,3-Benzenediol, 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, (1R-trans)- 2-(3-methyl-6-prop-1-en-2-yl-1-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol 3556-78-3 BDBM50121429 Cannabidiol solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis D0O1UZ Epidiolex (TN) UNII-19GBJ60SN5 (-)-CBD 1,3-Benzenediol,2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl- 2-(6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol (Cannabidiol) cannabidiolum QHMBSVQNZZTUGM-ZWKOTPCHSA-N ZYN002 (1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydrobiphenyl-2,6-diol 19GBJ60SN5 2-[3-Methyl-6-(methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol AC1LD8G2 Cannabidiol solution delta1(2)-trans-Cannabidiol Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)- (8CI) (-)-Cannabidiol 1,3-benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl- 2-(6-Isopropenyl-3-methyl-2-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol # BDBM50318484 Cannabidiol solution, ~10 mg/mL in ethanol, analytical standard, for drug analysis D1(2)-trans-Cannabidiol GTPL4150 UNII-K4H93P747O component QHMBSVQNZZTUGM-ZWKOTPCHSA-N (-)-trans-2-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol 13956-29-1 2-[(1R,6R)-3-methyl-6-prop-1-en-2-yl-1-cyclohex-2-enyl]-5-pentylbenzene-1,3-diol Cannabidiol (7CI) CBD DB09061 Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, (+-)- (3R,4R)-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinol 2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol 20547-66-4 AKOS032948358 Cannabidiol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material CHEMBL190461 Epidiolex SCHEMBL119679 (-)-Cannabidiol 1.0 mg/ml in Methanol 1,3-Benzenediol, 2-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, (1R-trans)- 2-(6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol 4CN-1161 C07578 Cannabidiol [USAN] D10915 GWP42003-P ZINC4097406 [ Show all ]
Inchi Key	QHMBSVQNZZTUGM-ZWKOTPCHSA-N
Inchi ID	InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
PubChem CID	644019
ChEMBL	CHEMBL190461
IUPHAR	4150
BindingDB	50121429, 50318484
DrugBank	DB09061
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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