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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS000735390
Molecular formula	C19H25ClN2O2
IUPAC name	1-[4-[3-(3-chlorobenzoyl)piperidin-1-yl]piperidin-1-yl]ethanone
Molecular weight	348.871
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.8
Synonyms	CHEMBL1562790 1-[4-[3-(3-chlorobenzoyl)piperidino]piperidino]ethanone BDBM90434 cid_16192411 (1'-acetyl-1,4'-bipiperidin-3-yl)(3-chlorophenyl)methanone SMR000318236 1-[4-[3-(3-chlorophenyl)carbonylpiperidin-1-yl]piperidin-1-yl]ethanone HMS2632M07 1-[4-[3-(3-chlorobenzoyl)piperidin-1-yl]piperidin-1-yl]ethanone 1-[4-[3-[(3-chlorophenyl)-oxomethyl]-1-piperidinyl]-1-piperidinyl]ethanone [ Show all ]
Inchi Key	DABYACYEBJAZDI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25ClN2O2/c1-14(23)21-10-7-18(8-11-21)22-9-3-5-16(13-22)19(24)15-4-2-6-17(20)12-15/h2,4,6,12,16,18H,3,5,7-11,13H2,1H3
PubChem CID	16192411
ChEMBL	CHEMBL1562790
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	763.6 nM	PubChem BioAssay data set	ChEMBL

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