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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	MLS000735390
Molecular formula	C19H25ClN2O2
IUPAC name	1-[4-[3-(3-chlorobenzoyl)piperidin-1-yl]piperidin-1-yl]ethanone
Molecular weight	348.871
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.8
Synonyms	1-[4-[3-(3-chlorobenzoyl)piperidin-1-yl]piperidin-1-yl]ethanone HMS2632M07 1-[4-[3-[(3-chlorophenyl)-oxomethyl]-1-piperidinyl]-1-piperidinyl]ethanone CHEMBL1562790 1-[4-[3-(3-chlorobenzoyl)piperidino]piperidino]ethanone BDBM90434 (1'-acetyl-1,4'-bipiperidin-3-yl)(3-chlorophenyl)methanone cid_16192411 1-[4-[3-(3-chlorophenyl)carbonylpiperidin-1-yl]piperidin-1-yl]ethanone SMR000318236 [ Show all ]
Inchi Key	DABYACYEBJAZDI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25ClN2O2/c1-14(23)21-10-7-18(8-11-21)22-9-3-5-16(13-22)19(24)15-4-2-6-17(20)12-15/h2,4,6,12,16,18H,3,5,7-11,13H2,1H3
PubChem CID	16192411
ChEMBL	CHEMBL1562790
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92470.0 nM	PubChem BioAssay data set	ChEMBL

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