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Name | 5-hydroxytryptamine receptor 7 |
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Species | Homo sapiens (Human) |
Gene | HTR7 |
Synonym | 5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 [ Show all ] |
Disease | Sleep disorders Schizophrenia Major depressive disorder |
Length | 479 |
Amino acid sequence | MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD |
UniProt | P34969 |
Protein Data Bank | N/A |
GPCR-HGmod model | P34969 |
3D structure model | This predicted structure model is from GPCR-EXP P34969. |
BioLiP | N/A |
Therapeutic Target Database | T79062 |
ChEMBL | CHEMBL3155 |
IUPHAR | 12 |
DrugBank | BE0000650, BE0004862 |
Name | CHEMBL3984812 |
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Molecular formula | C25H27ClN2O2 |
IUPAC name | 1-[[4-chloro-3-(2-methoxyphenyl)phenyl]methyl]-4-(2-methoxyphenyl)piperazine |
Molecular weight | 422.953 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 5.5 |
Synonyms | BDBM50204666 |
Inchi Key | APJODNDBBZDIBK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H27ClN2O2/c1-29-24-9-5-3-7-20(24)21-17-19(11-12-22(21)26)18-27-13-15-28(16-14-27)23-8-4-6-10-25(23)30-2/h3-12,17H,13-16,18H2,1-2H3 |
PubChem CID | 134157289 |
ChEMBL | CHEMBL3984812 |
IUPHAR | N/A |
BindingDB | 50204666 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Emax | -7.72 % | PMID27475109 | ChEMBL |
IC50 | 22908.7 nM | PMID27475109 | ChEMBL |
IC50 | 22909.0 nM | PMID27475109 | BindingDB |
IC50 | 23100.0 nM | PMID27475109 | BindingDB,ChEMBL |
Imax | 91.03 % | PMID27475109 | ChEMBL |
Ki | 73.0 nM | PMID27475109 | BindingDB,ChEMBL |
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