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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL119591
Molecular formula	C27H27N3O3
IUPAC name	N-[4-(5-acetamido-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide
Molecular weight	441.531
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.8
Synonyms	N-[4-[[[2,3,4,5-Tetrahydro-5-(acetylamino)-1H-1-benzazepin]-1-yl]carbonyl]phenyl]-2-methylbenzamide SCHEMBL7349118 BDBM50052938 N-[4-(5-Acetylamino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide
Inchi Key	CZSKFSPXWDTUEY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H27N3O3/c1-18-8-3-4-9-22(18)26(32)29-21-15-13-20(14-16-21)27(33)30-17-7-11-24(28-19(2)31)23-10-5-6-12-25(23)30/h3-6,8-10,12-16,24H,7,11,17H2,1-2H3,(H,28,31)(H,29,32)
PubChem CID	10527129
ChEMBL	CHEMBL119591
IUPHAR	N/A
BindingDB	50052938
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	150.0 nM	PMID8784453	BindingDB,ChEMBL

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