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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Rattus norvegicus (Rat)
Gene	Grm4
Synonym	glutamate receptor GPRC1D mGlu4 receptor mGluR4
Disease	N/A for non-human GPCRs
Length	912
Amino acid sequence	MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
UniProt	P31423
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2787
IUPHAR	292
DrugBank	N/A

Ligand

Name	D-2-aminoadipic acid
Molecular formula	C6H11NO4
IUPAC name	(2R)-2-aminohexanedioic acid
Molecular weight	161.157
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.1
Synonyms	ANW-43726 CHEMBL1169505 DTXSID90227062 KS-00000JOF RTR-032385 BDBM85356 H-D-Aad-OH M-3011 ST2402617 (R)-2-Aminoadipic acid AC1L4WZI AK-44090 CHEBI:37025 D-Homoglutamic acid K303 MolPort-003-925-532 Z2767445962 2-Aminohexanedioic acid (-)- and (+)- AS-14204 CTK3J3823 FT-0636535 KSC493Q2H SC-10039 (2R)-2-aminohexanedioic acid AB0014153 CA-639 D-2-Aminoadipic acid, 98% Hexanedioic acid, 2-amino-, (-)- and (+)- MFCD00063118 TR-032385 (R)-2-Aminohexanedioic acid AC1Q4UAX alpha-Aminoadipate, D- D-\|A-Aminoadipic acid KB-50502 NCGC00015087-01 ZINC1678992 7620-28-2 BC275520 D--Aminoadipic acid;(R)-2-Aminohexanedioic acid;H-D-Homoglu-OH H-D-2-Aad-OH Lopac-A-7275 SCHEMBL2022365 (R)-2-Amino-hexanedioic acid AC-22381 AJ-29561 CAS_542-32-5 D-a-Aminoadipic acid Hexanedioic acid, 2-amino-, (2R)- MFCD00063119 UNII-1K7B1OED4N component OYIFNHCXNCRBQI-SCSAIBSYSA-N (S)-2-Aminoadipic acid [ Show all ]
Inchi Key	OYIFNHCXNCRBQI-SCSAIBSYSA-N
Inchi ID	InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m1/s1
PubChem CID	165627
ChEMBL	CHEMBL1169505
IUPHAR	N/A
BindingDB	85356
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9696422	BindingDB

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