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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Mus musculus (Mouse)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	513
Amino acid sequence	MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P32240
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2489
IUPHAR	343
DrugBank	N/A

Ligand

Name	CHEMBL1094813
Molecular formula	C32H39NO4
IUPAC name	3-[4-[(2,5-dimethylphenoxy)methyl]-2-[[(1R)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid
Molecular weight	501.667
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	7.1
Synonyms	SCHEMBL2979528 3-[4-[(2,5-Dimethylphenoxy)methyl]-2-({[(1R)-1-(3,5-dimethylphenyl)-3-methylbutyl]amino}carbonyl)phenyl]-propanoic acid BDBM50317895
Inchi Key	CZGCGANYIFZAMH-GDLZYMKVSA-N
Inchi ID	InChI=1S/C32H39NO4/c1-20(2)13-29(27-15-22(4)14-23(5)16-27)33-32(36)28-18-25(9-10-26(28)11-12-31(34)35)19-37-30-17-21(3)7-8-24(30)6/h7-10,14-18,20,29H,11-13,19H2,1-6H3,(H,33,36)(H,34,35)/t29-/m1/s1
PubChem CID	11562422
ChEMBL	CHEMBL1094813
IUPHAR	N/A
BindingDB	50317895
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	92.0 nM	PMID20385498	BindingDB,ChEMBL

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