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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(3) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd3
Synonym	D3 receptor D3R Dopamine D3 receptor dopaminergic receptor D3
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UniProt	P19020
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3138
IUPHAR	216
DrugBank	N/A

Ligand

Name	CHEMBL413554
Molecular formula	C20H21FN2O
IUPAC name	2-(1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)-1-(4-fluorophenyl)ethanone
Molecular weight	324.399
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.8
Synonyms	BDBM50162860 1-(4-Fluoro-phenyl)-2-(1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinolin-3-yl)-ethanone
Inchi Key	AHBVUZZQOFAMJW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21FN2O/c21-17-8-5-16(6-9-17)20(24)14-22-11-12-23-18(13-22)10-7-15-3-1-2-4-19(15)23/h1-6,8-9,18H,7,10-14H2
PubChem CID	44390226
ChEMBL	CHEMBL413554
IUPHAR	N/A
BindingDB	50162860
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7487.0 nM	PMID15745825	BindingDB,ChEMBL

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