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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	CHEMBL3896591
Molecular formula	C17H17FN4O3S2
IUPAC name	5-amino-N-[(3-fluoro-4-methylsulfonylphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
Molecular weight	408.466
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	2.3
Synonyms	BDBM50207525 SCHEMBL15222563
Inchi Key	LGEGCVPUCXJWNX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H17FN4O3S2/c1-8-9(2)21-22-17-13(8)14(19)15(26-17)16(23)20-7-10-4-5-12(11(18)6-10)27(3,24)25/h4-6H,7,19H2,1-3H3,(H,20,23)
PubChem CID	89777153
ChEMBL	CHEMBL3896591
IUPHAR	N/A
BindingDB	50207525
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	57.54 nM	PMID27939174	ChEMBL
EC50	57.7 nM	PMID27939174	ChEMBL
EC50	58.0 nM	PMID27939174	BindingDB
Emax	69.2 %	PMID27939174	ChEMBL

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