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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	CHEMBL3942363
Molecular formula	C17H15F3N4O3S2
IUPAC name	5-amino-N-[[4-(difluoromethylsulfonyl)-3-fluorophenyl]methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
Molecular weight	444.447
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	3.2
Synonyms	BDBM50207526 SCHEMBL15222521
Inchi Key	JOTCDPLGFQRPSE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H15F3N4O3S2/c1-7-8(2)23-24-16-12(7)13(21)14(28-16)15(25)22-6-9-3-4-11(10(18)5-9)29(26,27)17(19)20/h3-5,17H,6,21H2,1-2H3,(H,22,25)
PubChem CID	89777113
ChEMBL	CHEMBL3942363
IUPHAR	N/A
BindingDB	50207526
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	23.0 nM	PMID27939174	BindingDB
EC50	23.4 nM	PMID27939174	ChEMBL
EC50	23.44 nM	PMID27939174	ChEMBL
Emax	76.7 %	PMID27939174	ChEMBL

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