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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 10
Species	Homo sapiens (Human)
Gene	CCR10
Synonym	CCR-10 CCR10 CC-CKR-10 G-protein coupled receptor 2 GPR-2 C-C CKR-10 [ Show all ]
Disease	Inflammatory disease
Length	362
Amino acid sequence	MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProt	P46092
Protein Data Bank	N/A
GPCR-HGmod model	P46092
3D structure model	This predicted structure model is from GPCR-EXP P46092.
BioLiP	N/A
Therapeutic Target Database	T71054
ChEMBL	CHEMBL2321628
IUPHAR	67
DrugBank	N/A

Ligand

Name	CHEMBL3933303
Molecular formula	C23H31N5O3S
IUPAC name	3-amino-N-[4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-2,4-dimethylbenzenesulfonamide
Molecular weight	457.593
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.6
Synonyms	BDBM50199041 SCHEMBL1076696
Inchi Key	HYZFJWMTMNERTK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H31N5O3S/c1-16-8-12-28(13-9-16)23(29)20(10-14-27-11-4-5-19(27)15-24)26-32(30,31)21-7-6-17(2)22(25)18(21)3/h4-7,11,16,20,26H,8-10,12-14,25H2,1-3H3
PubChem CID	58509165
ChEMBL	CHEMBL3933303
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	79.43 nM	PMID27692854	ChEMBL
IC50	100.0 nM	PMID27692854	ChEMBL

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