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Name | 5-hydroxytryptamine receptor 2A |
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Species | Mus musculus (Mouse) |
Gene | Htr2a |
Synonym | serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 471 |
Amino acid sequence | MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV |
UniProt | P35363 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5377 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL3936182 |
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Molecular formula | C21H27N3O2 |
IUPAC name | (2S)-4-[2-(2,3-dihydroindol-1-yl)ethyl]-2-[(6-methylpyridin-3-yl)oxymethyl]morpholine |
Molecular weight | 353.466 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 2.8 |
Synonyms | US9079895, 28s BDBM186944 SCHEMBL14061583 |
Inchi Key | DQFUJEZGAUMKKT-FQEVSTJZSA-N |
Inchi ID | InChI=1S/C21H27N3O2/c1-17-6-7-19(14-22-17)26-16-20-15-23(12-13-25-20)10-11-24-9-8-18-4-2-3-5-21(18)24/h2-7,14,20H,8-13,15-16H2,1H3/t20-/m0/s1 |
PubChem CID | 71062579 |
ChEMBL | CHEMBL3936182 |
IUPHAR | N/A |
BindingDB | 186944 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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Ki | 1482.0 nM | None | ChEMBL |
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