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Name | Oxytocin receptor |
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Species | Homo sapiens (Human) |
Gene | OXTR |
Synonym | OTR OT-R OT receptor |
Disease | Threatened pre-term labour Postpartum haemorrhage Premature ejaculation Miscarriage Female sexual dysfunction [ Show all ] |
Length | 389 |
Amino acid sequence | MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA |
UniProt | P30559 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30559 |
3D structure model | This predicted structure model is from GPCR-EXP P30559. |
BioLiP | N/A |
Therapeutic Target Database | T84486 |
ChEMBL | CHEMBL2049 |
IUPHAR | 369 |
DrugBank | BE0000844 |
Name | d[Leu4]AVP |
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Molecular formula | C47H67N13O11S2 |
IUPAC name | (2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-10-(2-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
Molecular weight | 1054.25 |
Hydrogen bond acceptor | 14 |
Hydrogen bond donor | 12 |
XlogP | -1.5 |
Synonyms | D0A6FK CHEMBL265859 BDBM50205313 |
Inchi Key | CYOLRNSRVHAZDY-QJCLFNHPSA-N |
Inchi ID | InChI=1S/C47H67N13O11S2/c1-26(2)20-31-41(66)58-34(23-37(48)62)44(69)59-35(46(71)60-18-7-11-36(60)45(70)55-30(10-6-17-52-47(50)51)40(65)53-24-38(49)63)25-73-72-19-16-39(64)54-32(22-28-12-14-29(61)15-13-28)42(67)57-33(43(68)56-31)21-27-8-4-3-5-9-27/h3-5,8-9,12-15,26,30-36,61H,6-7,10-11,16-25H2,1-2H3,(H2,48,62)(H2,49,63)(H,53,65)(H,54,64)(H,55,70)(H,56,68)(H,57,67)(H,58,66)(H,59,69)(H4,50,51,52)/t30-,31-,32-,33-,34-,35-,36-/m0/s1 |
PubChem CID | 44419029 |
ChEMBL | CHEMBL265859 |
IUPHAR | N/A |
BindingDB | 50205313 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 0.67 U/mg | PMID17300166 | ChEMBL |
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