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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cysteinyl leukotriene receptor 1
Species	Homo sapiens (Human)
Gene	CYSLTR1
Synonym	LTD4 receptor LTD4 leukotriene D4 receptor HMTMF81 HG55 G-protein coupled receptor HG55 CysLT1 receptor Cysteinyl leukotriene D4 receptor CysLTR1 CYSLT1R [ Show all ]
Disease	N/A
Length	337
Amino acid sequence	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
UniProt	Q9Y271
Protein Data Bank	N/A
GPCR-HGmod model	Q9Y271
3D structure model	This predicted structure model is from GPCR-EXP Q9Y271.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1798
IUPHAR	269
DrugBank	BE0000705

Ligand

Name	CHEMBL3920609
Molecular formula	C24H23N5O4
IUPAC name	1-[2-hydroxy-3-propyl-4-[[6-[3-(2H-tetrazol-5-yl)phenoxy]pyridin-3-yl]methoxy]phenyl]ethanone
Molecular weight	445.479
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	4.6
Synonyms	BDBM50207412 SCHEMBL3163622
Inchi Key	CKLHBXPMCQHQLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H23N5O4/c1-3-5-20-21(10-9-19(15(2)30)23(20)31)32-14-16-8-11-22(25-13-16)33-18-7-4-6-17(12-18)24-26-28-29-27-24/h4,6-13,31H,3,5,14H2,1-2H3,(H,26,27,28,29)
PubChem CID	59599616
ChEMBL	CHEMBL3920609
IUPHAR	N/A
BindingDB	50207412
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	484.0 nM	PMID27908761	BindingDB,ChEMBL

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