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Name | Proteinase-activated receptor 1 |
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Species | Homo sapiens (Human) |
Gene | F2R |
Synonym | Coagulation factor II receptor PAR-1 coagulation factor II (thrombin) receptor protease-activated receptor 1 Thrombin receptor [ Show all ] |
Disease | Thrombosis Restenosis Myocardial infarction Cancer Atherosclerosis [ Show all ] |
Length | 425 |
Amino acid sequence | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT |
UniProt | P25116 |
Protein Data Bank | 3vw7 |
GPCR-HGmod model | P25116 |
3D structure model | This structure is from PDB ID 3vw7. |
BioLiP | BL0217099 |
Therapeutic Target Database | T36483 |
ChEMBL | CHEMBL3974 |
IUPHAR | 347 |
DrugBank | BE0000928 |
Name | CHEMBL3964337 |
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Molecular formula | C25H24ClF2N5O2 |
IUPAC name | (3R,4R,5S,7aR)-4-[(E)-2-[5-(2-chlorophenyl)pyridin-2-yl]ethenyl]-6,6-difluoro-3,5-dimethyl-7a-(2H-tetrazol-5-ylmethyl)-3a,4,5,7-tetrahydro-3H-2-benzofuran-1-one |
Molecular weight | 499.947 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 1 |
XlogP | 5.1 |
Synonyms | BDBM230693 US9340530, 27 |
Inchi Key | BOXQIKNFMZYQCE-YNSSLRNISA-N |
Inchi ID | InChI=1S/C25H24ClF2N5O2/c1-14-18(10-9-17-8-7-16(12-29-17)19-5-3-4-6-20(19)26)22-15(2)35-23(34)24(22,13-25(14,27)28)11-21-30-32-33-31-21/h3-10,12,14-15,18,22H,11,13H2,1-2H3,(H,30,31,32,33)/b10-9+/t14-,15+,18-,22?,24+/m0/s1 |
PubChem CID | 127053961 |
ChEMBL | CHEMBL3964337 |
IUPHAR | N/A |
BindingDB | 230693 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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IC50 | 7.5 nM | , None | BindingDB,ChEMBL |
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