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Name | Proteinase-activated receptor 1 |
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Species | Homo sapiens (Human) |
Gene | F2R |
Synonym | Coagulation factor II receptor PAR-1 coagulation factor II (thrombin) receptor protease-activated receptor 1 Thrombin receptor [ Show all ] |
Disease | Thrombosis Restenosis Myocardial infarction Cancer Atherosclerosis [ Show all ] |
Length | 425 |
Amino acid sequence | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT |
UniProt | P25116 |
Protein Data Bank | 3vw7 |
GPCR-HGmod model | P25116 |
3D structure model | This structure is from PDB ID 3vw7. |
BioLiP | BL0217099 |
Therapeutic Target Database | T36483 |
ChEMBL | CHEMBL3974 |
IUPHAR | 347 |
DrugBank | BE0000928 |
Name | CHEMBL3909563 |
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Molecular formula | C25H23ClF2N2O2 |
IUPAC name | 2-[(1R,3aR,6S,7R)-7-[(E)-2-[5-(2-chlorophenyl)pyridin-2-yl]ethenyl]-5,5-difluoro-1,6-dimethyl-3-oxo-4,6,7,7a-tetrahydro-1H-2-benzofuran-3a-yl]acetonitrile |
Molecular weight | 456.918 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 5.3 |
Synonyms | BDBM230691 US9340530, 25 |
Inchi Key | BFIIOBKKPXNIRP-NMPKDNOQSA-N |
Inchi ID | InChI=1S/C25H23ClF2N2O2/c1-15-19(22-16(2)32-23(31)24(22,11-12-29)14-25(15,27)28)10-9-18-8-7-17(13-30-18)20-5-3-4-6-21(20)26/h3-10,13,15-16,19,22H,11,14H2,1-2H3/b10-9+/t15-,16+,19-,22?,24+/m0/s1 |
PubChem CID | 127053959 |
ChEMBL | CHEMBL3909563 |
IUPHAR | N/A |
BindingDB | 230691 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 3.3 nM | , None | BindingDB,ChEMBL |
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