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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 1
Species	Homo sapiens (Human)
Gene	F2R
Synonym	Coagulation factor II receptor PAR-1 coagulation factor II (thrombin) receptor protease-activated receptor 1 Thrombin receptor PAR1 [ Show all ]
Disease	Thrombosis Restenosis Myocardial infarction Cancer Atherosclerosis Acute coronary syndrome [ Show all ]
Length	425
Amino acid sequence	MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
UniProt	P25116
Protein Data Bank	3vw7
GPCR-HGmod model	P25116
3D structure model	This structure is from PDB ID 3vw7.
BioLiP	BL0217099
Therapeutic Target Database	T36483
ChEMBL	CHEMBL3974
IUPHAR	347
DrugBank	BE0000928

Ligand

Name	CHEMBL3952681
Molecular formula	C27H28ClF2N3O3
IUPAC name	2-[6-[(E)-2-[(3R,3aS,4R,5S,7aS)-7a-[(3-chloro-2-hydroxypropyl)amino]-6,6-difluoro-3,5-dimethyl-1-oxo-3a,4,5,7-tetrahydro-3H-2-benzofuran-4-yl]ethenyl]pyridin-3-yl]benzonitrile
Molecular weight	515.986
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	4.3
Synonyms	US9340530, 52 BDBM230717 SCHEMBL16406118
Inchi Key	BCGQRHBCZBYHOP-AIOHHJSDSA-N
Inchi ID	InChI=1S/C27H28ClF2N3O3/c1-16-22(10-9-20-8-7-19(13-32-20)23-6-4-3-5-18(23)12-31)24-17(2)36-25(35)26(24,15-27(16,29)30)33-14-21(34)11-28/h3-10,13,16-17,21-22,24,33-34H,11,14-15H2,1-2H3/b10-9+/t16-,17+,21?,22-,24-,26-/m0/s1
PubChem CID	117826532
ChEMBL	CHEMBL3952681
IUPHAR	N/A
BindingDB	230717
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.3 nM	, None	BindingDB,ChEMBL

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