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GPCR

NameFree fatty acid receptor 2
SpeciesMus musculus (Mouse)
GeneFfar2
SynonymFFA2 receptor
FFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length330
Amino acid sequenceMTPDWHSSLILTAYILIFLTGLPANLLALRAFMGRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISMERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQEQLDVVLPVRLELCLVLFFVPMAVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFYLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLIRNPASSMLGRGAKETVEGTKMDRGGSQAEGVQSSEFVTE
UniProtQ8VCK6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3309047
IUPHARN/A
DrugBankN/A

Ligand

NameAMG-7703
Molecular formulaC14H15ClN2OS
IUPAC name(2S)-2-(4-chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide
Molecular weight294.797
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.1
SynonymsAKOS022180360
GTPL5803
(S)-2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide
AMG7703
AC1LGZ5A
[ Show all ]
Inchi KeyAZYDQCGCBQYFSE-LBPRGKRZSA-N
Inchi IDInChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18)/t12-/m0/s1
PubChem CID854189
ChEMBLCHEMBL594671
IUPHAR5803
BindingDB50305974
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity1.0 uMPMID20005104ChEMBL

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