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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Homo sapiens (Human)
Gene	CHRM3
Synonym	cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 M3 receptor M3R [ Show all ]
Disease	Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease Glaucoma Diagnosing bronchial hyperreactivity Chronic obstructive pulmonary disease Seborrhea Sjogren's syndrome Spasms; Pain Unspecified Alzheimer disease Obstructive lung diseases [ Show all ]
Length	590
Amino acid sequence	MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
UniProt	P20309
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T67684
ChEMBL	CHEMBL245
IUPHAR	15
DrugBank	BE0000045

Ligand

Name	171722-92-2
Molecular formula	C18H20N2O2
IUPAC name	piperidin-4-yl N-(2-phenylphenyl)carbamate
Molecular weight	296.37
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.5
Synonyms	Biphenyl-2-yl-carbamic acid piperidin-4-yl ester N-(1,1'-Biphenyl-2-yl)carbamic acid 4-piperidinyl ester 4-Piperidyl N-(2-biphenyl)carbamate@CRLF171722-92-2 Carbamic acid, [1,1'-biphenyl]-2-yl-, 4-piperidinyl ester SCHEMBL264806 AGZCCVMWUZINGV-UHFFFAOYSA-N CTK0E4634 Biphenyl-2-ylcarbamic Acid Piperidin-4-yl Ester piperidin-4-yl biphenyl-2-ylcarbamate 4-piperidyl N-(2-biphenylyl)carbamate BDBM50337879 DTXSID00445856 Biphenyl-2-ylcarbamic Acid Piperidin4-yl Ester piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate CHEMBL1683908 [ Show all ]
Inchi Key	AGZCCVMWUZINGV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2O2/c21-18(22-15-10-12-19-13-11-15)20-17-9-5-4-8-16(17)14-6-2-1-3-7-14/h1-9,15,19H,10-13H2,(H,20,21)
PubChem CID	10851461
ChEMBL	CHEMBL1683908
IUPHAR	N/A
BindingDB	50337879
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	46.0 nM	PMID21310610	BindingDB,ChEMBL

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