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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanocortin receptor 5
Species	Homo sapiens (Human)
Gene	MC5R
Synonym	melanocortin receptor 5 MC5R MC5-R MC5 receptor MC-2
Disease	Acne vulgaris Seborrhea
Length	325
Amino acid sequence	MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
UniProt	P33032
Protein Data Bank	N/A
GPCR-HGmod model	P33032
3D structure model	This predicted structure model is from GPCR-EXP P33032.
BioLiP	N/A
Therapeutic Target Database	T95302
ChEMBL	CHEMBL4608
IUPHAR	286
DrugBank	N/A

Ligand

Name	CHEMBL3975125
Molecular formula	C33H43ClN4O4S
IUPAC name	N-[[(3R,5R)-3-[2-(butylsulfonylamino)ethyl]-2-oxo-1-[(2S)-2-phenylbutyl]-1,4-diazepan-5-yl]methyl]-6-chloronaphthalene-2-carboxamide
Molecular weight	627.241
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	5.8
Synonyms	BDBM232175 US9340517, 563
Inchi Key	BLCUZMOUSGKIFR-RYHYHUEASA-N
Inchi ID	InChI=1S/C33H43ClN4O4S/c1-3-5-19-43(41,42)36-17-15-31-33(40)38(23-24(4-2)25-9-7-6-8-10-25)18-16-30(37-31)22-35-32(39)28-12-11-27-21-29(34)14-13-26(27)20-28/h6-14,20-21,24,30-31,36-37H,3-5,15-19,22-23H2,1-2H3,(H,35,39)/t24-,30-,31-/m1/s1
PubChem CID	127054361
ChEMBL	CHEMBL3975125
IUPHAR	N/A
BindingDB	232175
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	>1000.0 nM	, None	BindingDB,ChEMBL

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