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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanocortin receptor 5
Species	Homo sapiens (Human)
Gene	MC5R
Synonym	melanocortin receptor 5 MC5R MC5-R MC5 receptor MC-2
Disease	Acne vulgaris Seborrhea
Length	325
Amino acid sequence	MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
UniProt	P33032
Protein Data Bank	N/A
GPCR-HGmod model	P33032
3D structure model	This predicted structure model is from GPCR-EXP P33032.
BioLiP	N/A
Therapeutic Target Database	T95302
ChEMBL	CHEMBL4608
IUPHAR	286
DrugBank	N/A

Ligand

Name	SCHEMBL2347568
Molecular formula	C37H42N6O3
IUPAC name	N-[[(3S,5S)-3-[3-(diaminomethylideneamino)propyl]-1-(2,2-diphenylethyl)-2-oxo-1,4-diazepan-5-yl]methyl]-3-phenoxybenzamide
Molecular weight	618.782
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	4.6
Synonyms	US9340517, 140 CHEMBL3905956 BDBM231754
Inchi Key	BGYBDRQRKARBIH-NHZFLZHXSA-N
Inchi ID	InChI=1S/C37H42N6O3/c38-37(39)40-22-11-20-34-36(45)43(26-33(27-12-4-1-5-13-27)28-14-6-2-7-15-28)23-21-30(42-34)25-41-35(44)29-16-10-19-32(24-29)46-31-17-8-3-9-18-31/h1-10,12-19,24,30,33-34,42H,11,20-23,25-26H2,(H,41,44)(H4,38,39,40)/t30-,34-/m0/s1
PubChem CID	46897821
ChEMBL	CHEMBL3905956
IUPHAR	N/A
BindingDB	231754
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	>100.0 nM	, None	BindingDB,ChEMBL

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