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GPCR

NameC-X-C chemokine receptor type 5
SpeciesHomo sapiens (Human)
GeneCXCR5
SynonymBLR-1
NLR
neurolymphatic receptor
Monocyte-derived receptor 15
MDR15
[ Show all ]
DiseaseSystemic lupus erythematosus
Length372
Amino acid sequenceMNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
UniProtP32302
Protein Data BankN/A
GPCR-HGmod modelP32302
3D structure modelThis predicted structure model is from GPCR-EXP P32302.
BioLiPN/A
Therapeutic Target DatabaseT09528
ChEMBLCHEMBL1075315
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL3309864
Molecular formulaC21H16FNO3
IUPAC name2-[(4-fluoronaphthalene-1-carbonyl)amino]-1,3-dihydroindene-2-carboxylic acid
Molecular weight349.361
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.0
SynonymsCHEMBL3716580
2-[(4-Fluoro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
XODOKYPWIGGVJM-UHFFFAOYSA-N
Inchi KeyXODOKYPWIGGVJM-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H16FNO3/c22-18-10-9-17(15-7-3-4-8-16(15)18)19(24)23-21(20(25)26)11-13-5-1-2-6-14(13)12-21/h1-10H,11-12H2,(H,23,24)(H,25,26)
PubChem CID59314112
ChEMBLCHEMBL3716580
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5013000.0 nMNoneChEMBL

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