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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	SMR000025325
Molecular formula	C19H19N3O2S
IUPAC name	N-(2-ethoxyphenyl)-2-(1-phenylimidazol-2-yl)sulfanylacetamide
Molecular weight	353.44
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	AC1MMO5T HMS2299E05 N-(2-ethoxyphenyl)-2-[(1-phenyl-1H-imidazol-2-yl)thio]acetamide MLS000090721 F0599-0049 N-(2-ethoxyphenyl)-2-(1-phenylimidazol-2-yl)sulfanyl-ethanamide ZINC2723006 AKOS024585909 IFLab1_002719 N-(2-ethoxyphenyl)-2-[(1-phenyl-2-imidazolyl)thio]acetamide CHEMBL1343699 MolPort-003-031-190 SR-01000123298 688335-54-8 HMS1419L13 N-(2-ethoxyphenyl)-2-(1-phenylimidazol-2-yl)sulfanylacetamide BDBM37727 MCULE-7664758161 N-o-phenetyl-2-[(1-phenylimidazol-2-yl)thio]acetamide cid_3241796 N-(2-ethoxyphenyl)-2-((1-phenyl-1H-imidazol-2-yl)thio)acetamide SR-01000123298-1 [ Show all ]
Inchi Key	CXQUZZKPYSHPMV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H19N3O2S/c1-2-24-17-11-7-6-10-16(17)21-18(23)14-25-19-20-12-13-22(19)15-8-4-3-5-9-15/h3-13H,2,14H2,1H3,(H,21,23)
PubChem CID	3241796
ChEMBL	CHEMBL1343699
IUPHAR	N/A
BindingDB	37727
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB
Ki	<66700.0 nM	PubChem BioAssay data set	ChEMBL

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