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Name | C-C chemokine receptor type 10 |
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Species | Homo sapiens (Human) |
Gene | CCR10 |
Synonym | CCR-10 CCR10 CC-CKR-10 G-protein coupled receptor 2 GPR-2 [ Show all ] |
Disease | Inflammatory disease |
Length | 362 |
Amino acid sequence | MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN |
UniProt | P46092 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46092 |
3D structure model | This predicted structure model is from GPCR-EXP P46092. |
BioLiP | N/A |
Therapeutic Target Database | T71054 |
ChEMBL | CHEMBL2321628 |
IUPHAR | 67 |
DrugBank | N/A |
Name | CHEMBL3732275 |
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Molecular formula | C29H27Cl2FN6O5S |
IUPAC name | N-[7-(2,5-dichloroanilino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidin-3-yl]sulfonyl-3-methyloxetane-3-carboxamide |
Molecular weight | 661.53 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 4.5 |
Synonyms | OWNNWIKYYQTZRS-UHFFFAOYSA-N SCHEMBL14471998 N-{7-(2,5-dichlorophenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl}-3-methyloxetane-3-carboxamide |
Inchi Key | OWNNWIKYYQTZRS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H27Cl2FN6O5S/c1-29(15-43-16-29)28(40)36-44(41,42)24-14-34-38-25(35-23-12-19(30)4-7-22(23)31)21(13-33-26(24)38)27(39)37-10-8-18(9-11-37)17-2-5-20(32)6-3-17/h2-7,12-14,18,35H,8-11,15-16H2,1H3,(H,36,40) |
PubChem CID | 71179085 |
ChEMBL | CHEMBL3732275 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | <100.0 % | None | ChEMBL |
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