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GPCR

NameC-X-C chemokine receptor type 5
SpeciesHomo sapiens (Human)
GeneCXCR5
SynonymBLR-1
NLR
neurolymphatic receptor
Monocyte-derived receptor 15
MDR15
[ Show all ]
DiseaseSystemic lupus erythematosus
Length372
Amino acid sequenceMNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
UniProtP32302
Protein Data BankN/A
GPCR-HGmod modelP32302
3D structure modelThis predicted structure model is from GPCR-EXP P32302.
BioLiPN/A
Therapeutic Target DatabaseT09528
ChEMBLCHEMBL1075315
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL3307291
Molecular formulaC22H23NO4
IUPAC name2-[[2-(cyclopropylmethoxy)-3-methylbenzoyl]amino]-1,3-dihydroindene-2-carboxylic acid
Molecular weight365.429
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.7
SynonymsCHEMBL3715405
2-(2-Cyclopropylmethoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
LQYWUXJBHFXOOE-UHFFFAOYSA-N
Inchi KeyLQYWUXJBHFXOOE-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H23NO4/c1-14-5-4-8-18(19(14)27-13-15-9-10-15)20(24)23-22(21(25)26)11-16-6-2-3-7-17(16)12-22/h2-8,15H,9-13H2,1H3,(H,23,24)(H,25,26)
PubChem CID59314401
ChEMBLCHEMBL3715405
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502930.0 nMNoneChEMBL

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