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GLASS

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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	SMR000046229
Molecular formula	C14H17BrN2O2
IUPAC name	N-(5-bromo-1-butyl-2-oxo-3H-indol-3-yl)acetamide
Molecular weight	325.206
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.3
Synonyms	MLS-0016686.0001 AKOS022011286 N-(5-bromanyl-1-butyl-2-oxidanylidene-3H-indol-3-yl)ethanamide HMS2274C15 N-(5-bromo-1-butyl-2-oxo-3H-indol-3-yl)acetamide AC1LDDEK MLS000083794 STK876248 BDBM62063 CHEMBL1579263 N-(5-bromo-1-butyl-2-keto-indolin-3-yl)acetamide 1008069-41-7 MCULE-3586567324 REGID_for_CID_665257 AKOS001710499 MolPort-002-626-825 CCG-121252 cid_665257 N-(5-bromo-1-butyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetamide [ Show all ]
Inchi Key	CXCGQPLUFMSASL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H17BrN2O2/c1-3-4-7-17-12-6-5-10(15)8-11(12)13(14(17)19)16-9(2)18/h5-6,8,13H,3-4,7H2,1-2H3,(H,16,18)
PubChem CID	665257
ChEMBL	CHEMBL1579263
IUPHAR	N/A
BindingDB	62063
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<43807.0 nM	PubChem BioAssay data set	ChEMBL

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