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GPCR

NameC-X-C chemokine receptor type 5
SpeciesHomo sapiens (Human)
GeneCXCR5
SynonymBLR-1
NLR
neurolymphatic receptor
Monocyte-derived receptor 15
MDR15
[ Show all ]
DiseaseSystemic lupus erythematosus
Length372
Amino acid sequenceMNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
UniProtP32302
Protein Data BankN/A
GPCR-HGmod modelP32302
3D structure modelThis predicted structure model is from GPCR-EXP P32302.
BioLiPN/A
Therapeutic Target DatabaseT09528
ChEMBLCHEMBL1075315
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL3309293
Molecular formulaC23H21NO4
IUPAC name2-[(2-ethoxynaphthalene-1-carbonyl)amino]-1,3-dihydroindene-2-carboxylic acid
Molecular weight375.424
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.2
SynonymsCHEMBL3714900
2-[(2-Ethoxy-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
HRPVFPJSKUAKRD-UHFFFAOYSA-N
Inchi KeyHRPVFPJSKUAKRD-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H21NO4/c1-2-28-19-12-11-15-7-5-6-10-18(15)20(19)21(25)24-23(22(26)27)13-16-8-3-4-9-17(16)14-23/h3-12H,2,13-14H2,1H3,(H,24,25)(H,26,27)
PubChem CID59314091
ChEMBLCHEMBL3714900
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5019600.0 nMNoneChEMBL

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